Evaluation of periodic limb movements in a putative animal model of restless leg syndrome.
Identifieur interne : 000D97 ( Main/Exploration ); précédent : 000D96; suivant : 000D98Evaluation of periodic limb movements in a putative animal model of restless leg syndrome.
Auteurs : Cleide Lopes [Brésil] ; Andrea M. Esteves ; Roberto Frussa-Filho ; Sergio Tufik ; Marco Tulio De MelloSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.
English descriptors
- KwdEn :
- Analysis of Variance, Animals, Antiparkinson Agents (therapeutic use), Benzothiazoles (therapeutic use), Disease Models, Animal, Electroencephalography, Electromyography, Extremities (physiopathology), Male, Movement (physiology), Nocturnal Myoclonus Syndrome (diagnosis), Nocturnal Myoclonus Syndrome (drug therapy), Nocturnal Myoclonus Syndrome (etiology), Oxidopamine (toxicity), Rats, Rats, Wistar, Restless Legs Syndrome (chemically induced), Restless Legs Syndrome (complications), Sympatholytics (toxicity), Time Factors, Tyrosine 3-Monooxygenase (metabolism), Ventral Tegmental Area (metabolism), Ventral Tegmental Area (pathology).
- MESH :
- chemical , metabolism : Tyrosine 3-Monooxygenase.
- chemical , therapeutic use : Antiparkinson Agents, Benzothiazoles.
- chemically induced : Restless Legs Syndrome.
- complications : Restless Legs Syndrome.
- diagnosis : Nocturnal Myoclonus Syndrome.
- drug therapy : Nocturnal Myoclonus Syndrome.
- etiology : Nocturnal Myoclonus Syndrome.
- metabolism : Ventral Tegmental Area.
- pathology : Ventral Tegmental Area.
- physiology : Movement.
- physiopathology : Extremities.
- chemical , toxicity : Oxidopamine, Sympatholytics.
- Analysis of Variance, Animals, Disease Models, Animal, Electroencephalography, Electromyography, Male, Rats, Rats, Wistar, Time Factors.
Abstract
Restless leg syndrome (RLS) is a major healthcare burden with increasing prevalence. It has been demonstrated that periodic limb movements (PLM) can occur as an isolated phenomenon, but they are often associated with this syndrome and are the only symptom of this disorder that can be measured electrophysiologically. The aim of this study was to examine the sleep-wake behavior and the presence of limb movement in a rat model of RLS induced by lesioning the A11 dopaminergic nuclei with the neurotoxin 6-hydroxydopamine (6-OHDA). Rats were implanted with electrodes for electrocorticography and electromyography. Sleep recordings were monitored during light/dark periods lasting 12 hours each and were evaluated on days 7, 15, and 28 after injection of the drug or phosphate-buffered saline (PBS). A control group that did not receive any injection was also included. Wakefulness percentages were generated for 4-hour segments of the dark period, yielding the following 3 bins: 7 PM to 11 PM, 11 PM to 3 AM, and 3 PM to 7 PM. Additionally, slow wave sleep, paradoxical sleep, wakefulness, and limb movements were evaluated over the entire 12 hours of the light/dark cycle. All A11-lesioned rats exhibited an increased percentage of wakefulness during the last block of the dark period, as would be expected for an animal model of this syndrome. In addition, at all time points after lesioning, these animals presented increased frequencies of limb movement during both the light and the dark periods. These alterations were reversed by the acute administration of the dopaminergic agonist pramipexole. This animal model strengthens the notion that 6-OHDA-induced A11 lesions can be a valid animal model for RLS and PLM.
DOI: 10.1002/mds.24058
PubMed: 22162115
Affiliations:
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Esteves</name></author><author><name sortKey="Frussa Filho, Roberto" sort="Frussa Filho, Roberto" uniqKey="Frussa Filho R" first="Roberto" last="Frussa-Filho">Roberto Frussa-Filho</name></author><author><name sortKey="Tufik, Sergio" sort="Tufik, Sergio" uniqKey="Tufik S" first="Sergio" last="Tufik">Sergio Tufik</name></author><author><name sortKey="De Mello, Marco Tulio" sort="De Mello, Marco Tulio" uniqKey="De Mello M" first="Marco Tulio" last="De Mello">Marco Tulio De Mello</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="doi">10.1002/mds.24058</idno><idno type="RBID">pubmed:22162115</idno><idno type="pmid">22162115</idno><idno type="wicri:Area/PubMed/Corpus">000F37</idno><idno type="wicri:Area/PubMed/Curation">000F37</idno><idno type="wicri:Area/PubMed/Checkpoint">000E33</idno><idno type="wicri:Area/Ncbi/Merge">003493</idno><idno type="wicri:Area/Ncbi/Curation">003493</idno><idno type="wicri:Area/Ncbi/Checkpoint">003493</idno><idno type="wicri:Area/Main/Merge">000E24</idno><idno type="wicri:Area/Main/Curation">000D97</idno><idno type="wicri:Area/Main/Exploration">000D97</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Evaluation of periodic limb movements in a putative animal model of restless leg syndrome.</title><author><name sortKey="Lopes, Cleide" sort="Lopes, Cleide" uniqKey="Lopes C" first="Cleide" last="Lopes">Cleide Lopes</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychobiology, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Psychobiology, Universidade Federal de São Paulo (UNIFESP), São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Esteves, Andrea M" sort="Esteves, Andrea M" uniqKey="Esteves A" first="Andrea M" last="Esteves">Andrea M. Esteves</name></author><author><name sortKey="Frussa Filho, Roberto" sort="Frussa Filho, Roberto" uniqKey="Frussa Filho R" first="Roberto" last="Frussa-Filho">Roberto Frussa-Filho</name></author><author><name sortKey="Tufik, Sergio" sort="Tufik, Sergio" uniqKey="Tufik S" first="Sergio" last="Tufik">Sergio Tufik</name></author><author><name sortKey="De Mello, Marco Tulio" sort="De Mello, Marco Tulio" uniqKey="De Mello M" first="Marco Tulio" last="De Mello">Marco Tulio De Mello</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance</term><term>Animals</term><term>Antiparkinson Agents (therapeutic use)</term><term>Benzothiazoles (therapeutic use)</term><term>Disease Models, Animal</term><term>Electroencephalography</term><term>Electromyography</term><term>Extremities (physiopathology)</term><term>Male</term><term>Movement (physiology)</term><term>Nocturnal Myoclonus Syndrome (diagnosis)</term><term>Nocturnal Myoclonus Syndrome (drug therapy)</term><term>Nocturnal Myoclonus Syndrome (etiology)</term><term>Oxidopamine (toxicity)</term><term>Rats</term><term>Rats, Wistar</term><term>Restless Legs Syndrome (chemically induced)</term><term>Restless Legs Syndrome (complications)</term><term>Sympatholytics (toxicity)</term><term>Time Factors</term><term>Tyrosine 3-Monooxygenase (metabolism)</term><term>Ventral Tegmental Area (metabolism)</term><term>Ventral Tegmental Area (pathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Tyrosine 3-Monooxygenase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Benzothiazoles</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Nocturnal Myoclonus Syndrome</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Nocturnal Myoclonus Syndrome</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Nocturnal Myoclonus Syndrome</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Ventral Tegmental Area</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Ventral Tegmental Area</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Movement</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Extremities</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Oxidopamine</term><term>Sympatholytics</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Animals</term><term>Disease Models, Animal</term><term>Electroencephalography</term><term>Electromyography</term><term>Male</term><term>Rats</term><term>Rats, Wistar</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Restless leg syndrome (RLS) is a major healthcare burden with increasing prevalence. It has been demonstrated that periodic limb movements (PLM) can occur as an isolated phenomenon, but they are often associated with this syndrome and are the only symptom of this disorder that can be measured electrophysiologically. The aim of this study was to examine the sleep-wake behavior and the presence of limb movement in a rat model of RLS induced by lesioning the A11 dopaminergic nuclei with the neurotoxin 6-hydroxydopamine (6-OHDA). Rats were implanted with electrodes for electrocorticography and electromyography. Sleep recordings were monitored during light/dark periods lasting 12 hours each and were evaluated on days 7, 15, and 28 after injection of the drug or phosphate-buffered saline (PBS). A control group that did not receive any injection was also included. Wakefulness percentages were generated for 4-hour segments of the dark period, yielding the following 3 bins: 7 PM to 11 PM, 11 PM to 3 AM, and 3 PM to 7 PM. Additionally, slow wave sleep, paradoxical sleep, wakefulness, and limb movements were evaluated over the entire 12 hours of the light/dark cycle. All A11-lesioned rats exhibited an increased percentage of wakefulness during the last block of the dark period, as would be expected for an animal model of this syndrome. In addition, at all time points after lesioning, these animals presented increased frequencies of limb movement during both the light and the dark periods. These alterations were reversed by the acute administration of the dopaminergic agonist pramipexole. This animal model strengthens the notion that 6-OHDA-induced A11 lesions can be a valid animal model for RLS and PLM.</div></front></TEI><affiliations><list><country><li>Brésil</li></country><region><li>État de São Paulo</li></region><settlement><li>São Paulo</li></settlement></list><tree><noCountry><name sortKey="De Mello, Marco Tulio" sort="De Mello, Marco Tulio" uniqKey="De Mello M" first="Marco Tulio" last="De Mello">Marco Tulio De Mello</name><name sortKey="Esteves, Andrea M" sort="Esteves, Andrea M" uniqKey="Esteves A" first="Andrea M" last="Esteves">Andrea M. Esteves</name><name sortKey="Frussa Filho, Roberto" sort="Frussa Filho, Roberto" uniqKey="Frussa Filho R" first="Roberto" last="Frussa-Filho">Roberto Frussa-Filho</name><name sortKey="Tufik, Sergio" sort="Tufik, Sergio" uniqKey="Tufik S" first="Sergio" last="Tufik">Sergio Tufik</name></noCountry><country name="Brésil"><region name="État de São Paulo"><name sortKey="Lopes, Cleide" sort="Lopes, Cleide" uniqKey="Lopes C" first="Cleide" last="Lopes">Cleide Lopes</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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